Allow Cross-Site POP3 and IMAP4 Client Connectivity

You can allow your POP3 and IMAP4 clients to connect to their mailbox from one site in your organization when their mailbox is located in a different site in your organization. This setting is not enabled by default. This feature can only be performed by using the Exchange Management Shell.
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Use the Shell to enable or disable cross-site POP3 or IMAP4 client connectivity

This example enables cross-site IMAP4 connectivity:
IMAP


Set-IMAPSettings -AllowCrossSiteSessions
This example enables cross-site POP3 connectivity:
POP


Set-POPSettings -AllowCrossSiteSessions
Restart the IMAP4 service or the POP3 service. You must restart the service you are using to start the process of replicating this settings change to all of your domain controllers.